Endocrine Abstracts

Background: It has been reported that metformin might modify thyroid hormone economy. This farmacological tool appears very useful in patients with differentiated thyroid cancer usually receiving high Levo-tiroxine (L-T4) doses to suppress thyrotropin (TSH). In those patients that after five years of follow-up showed no persistence of disease, it’s useful to abolish the iatrogenic hyperthyroid condition.Objective: To evaluate metformi...

Background: Insulin-resistance phenomenon is a key factor in the pathogenesis of Metabolic Syndrome (MS). Several reports focus on the identification of a role of Insulin to trigger thyrocytes proliferation in vitro. Thyroid IRS-1 mRNA expression increased progressively during goitrogenesis in vivo. In order to individuate the impact of clinical and biochemical markers of MS on the growth-score of non toxic multinodular goiter (MNG) we evaluated a population of 6...